Arizona Cardinals vs San Francisco 49ers: result and box score, 21 September 2025

NFL games

Final, Levi's Stadium

Cardinals

2–1

49ers

3–0

15FINAL16

Box score →

Matchup

Last 15 games

23.4Points per game21.9

20.5Points allowed25.9

231Passing yards256.7

137.7Rushing yards119.5

-0.2Turnover margin-0.73

Injuries

Will JohnsonARI, GroinDoubtful

Max MeltonARI, KneeQuestionable

Paris Johnson Jr.ARI, KneeQuestionable

Tip ReimanARI, FootQuestionable

Will HernandezARI, KneeQuestionable

Calais CampbellARI, Not injury related - resting playerDid Not Participate In Practice

Cody SimonARI, ConcussionFull Participation in Practice

Dante StillsARI, ElbowFull Participation in Practice

Kelvin BeachumARI, Not injury related - resting playerFull Participation in Practice

Jordan WatkinsSF, CalfOut

Spencer BurfordSF, KneeOut

Brock PurdySF, ShoulderQuestionable

Connor ColbySF, GroinQuestionable

Jauan JenningsSF, AnkleQuestionable

NFL matchupsCardinals @ 49ers

NFL MLB NBA

Away, 2–1

Cardinals

Home, 3–0

49ers

Sun 21 Sep, 21:25 UK, Levi's Stadium

15 – 16

Final. All results, Week 3 →

Box score

Team	Points	Passing yards	Rushing yards	Carries	Turnovers
Arizona Cardinals	15	159	106	28	0
San Francisco 49ers	16	284	73	20	1

Arizona Cardinals

Passing	C/ATT	YDS	TD	INT	SACKS
Kyler Murray	22/35	159	1	0	1

Rushing	CAR	YDS	LONG
Trey Benson	10	42	29
Kyler Murray	6	37	9
James Conner	9	22	9
Greg Dortch	1	5	5
Emari Demercado	2	0	1

Receiving	REC	TGT	YDS	TD	LONG
Marvin Harrison Jr.	3	6	44	0	32
Trey McBride	5	8	43	1	17
Zay Jones	2	3	25	0	18
James Conner	3	4	15	0	10
Trey Benson	3	4	9	0	5
Tip Reiman	2	3	8	0	6
Elijah Higgins	1	1	7	0	7
Michael Wilson	1	2	5	0	5
Greg Dortch	2	2	3	0	2
Emari Demercado	0	1	0	0	—

Kicking	FG	LONG	XP
Chad Ryland	2/3	34	1/1

Defence	TKL	SOLO	INT	PD
Mack Wilson	12	6	0	2
Akeem Davis-Gaither	8	5	0	0
Budda Baker	6	3	0	0
Jalen Thompson	6	4	0	0
Kei'Trel Clark	5	3	0	0
Dadrion Taylor-Demerson	4	4	1	1
Dalvin Tomlinson	3	2	0	0
Max Melton	3	2	0	0

San Francisco 49ers

Passing	C/ATT	YDS	TD	INT	SACKS
Mac Jones	27/41	284	1	1	1

Rushing	CAR	YDS	LONG
Christian McCaffrey	17	52	15
Brian Robinson	2	22	19
Mac Jones	1	-1	—

Receiving	REC	TGT	YDS	TD	LONG
Ricky Pearsall	8	11	117	0	34
Christian McCaffrey	10	15	88	0	20
Kendrick Bourne	4	6	38	0	11
Jake Tonges	2	3	21	0	11
Skyy Moore	1	1	10	0	10
Marquez Valdes-Scantling	1	1	9	0	9
Kyle Juszczyk	1	1	1	1	1

Kicking	FG	LONG	XP
Eddy Pineiro	3/3	51	1/1

Defence	TKL	SOLO	SACKS	PD
Fred Warner	11	5	0	2
Dee Winters	8	4	0	1
Sam Okuayinonu	7	2	0	0
Marques Sigle	7	2	0	0
Bryce Huff	5	2	1	1
Upton Stout	5	3	0	1
Ji'Ayir Brown	4	2	0	0
Renardo Green	4	1	0	0

Passing yards are before sacks. Defence shows each side's top tacklers.

Team comparison

Last 15 games before this one

Cardinals49ers

23.4 Points per game 21.9

20.5 Points allowed 25.9

231 Passing yards 256.7

137.7 Rushing yards 119.5

-0.2 Turnover margin -0.73

Injuries

Doubtful Will JohnsonARI, Groin

Questionable Max MeltonARI, Knee

Questionable Paris Johnson Jr.ARI, Knee

Questionable Tip ReimanARI, Foot

Questionable Will HernandezARI, Knee

Did Not Participate In Practice Calais CampbellARI, Not injury related - resting player

Full Participation in Practice Cody SimonARI, Concussion

Full Participation in Practice Dante StillsARI, Elbow

Full Participation in Practice Kelvin BeachumARI, Not injury related - resting player

Out Jordan WatkinsSF, Calf

Out Spencer BurfordSF, Knee

Questionable Brock PurdySF, Shoulder

Questionable Connor ColbySF, Groin

Questionable Jauan JenningsSF, Ankle